There are several other angiotensin receptor blockers that work in the same way as losartan. 12.5 mg daily, 25 mg daily, 50 mg daily, 100 mg daily, up to a maximum dose of 150 mg once daily), as tolerated by the patient. There may be other treatments that are safer for you. Therefore, concomitant use is not recommended (see section 4.5). This lowers your blood pressure and makes it easier for your heart to pump blood around your body. • Treatment of essential hypertension in adults and in children and adolescents 6 – 18 years of age. Your doctor will then decide whether to change your dose of losartan. Losartan was given at doses of 0.7 mg/kg to 1.4 mg/kg (up to maximum dose of 100 mg per day). This applies particularly when losartan is given in the presence of other conditions (fever, dehydration) likely to impair renal function. In the ELITE Study carried out over 48 weeks in 722 patients with heart failure (NYHA Class II-IV), no difference was observed between the patients treated with losartan and those treated with captopril was observed with regard to the primary endpoint of a long-term change in renal function. INSTRUCTIONS FOR PREPARATION OF RADIOPHARMACEUTICALS (IF APPLICABLE), Building 4, Trident Place, Mosquito Way, Hatfield, Hertfordshire, AL10 9UL. A low dose of hydrochlorothiazide should be added and/ or the dose of losartan should be increased to 100 mg once daily based on blood pressure response. The rise in trough diastolic blood pressure was the same in patients receiving placebo and in those continuing losartan at the lowest dose in each group, again suggesting that the lowest dose in each group did not have significant antihypertensive effect. I was down to 110/70 and even 100/65 at times. Losartan is not recommended in children with glomerular filtration rate < 30ml/ min/ 1.73 m2 as no data are available (see section 4.2). Breastfeeding . Menu • Treatment of chronic heart failure in adult patients , when treatment with angiotensin converting enzyme (ACE) inhibitors is not considered suitable due to incompatibility, especially cough, or contraindication. As with other vasodilators, special caution is indicated in patients suffering from aortic or mitral stenosis, or obstructive hypertrophic cardiomyopathy. To view the changes to a medicine you must sign up and log in. Although not all of these side effects may occur, if they do occur they may need medical attention. In patients with heart failure, with or without renal impairment, there is - as with other medicinal products acting on the renin-angiotensin system - a risk of severe arterial hypotension, and (often acute) renal impairment. Following oral administration, losartan is well absorbed and undergoes first-pass metabolism, forming an active carboxylic acid metabolite and other inactive metabolites. Start typing to retrieve search suggestions. The Losartan Intervention For Endpoint Reduction in Hypertension [LIFE] study was a randomised, triple-blind, active-controlled study in 9193 hypertensive patients aged 55 to 80 years with ECG documented] left-ventricular hypertrophy. I was getting the Losartan from Walgreens as … For Adult 76 years and over Initially 25 mg once daily for several weeks, then increased if necessary to 100 mg once daily. An increased mortality was observed in ELITE II in the small subgroup (22% of all HF patients) taking beta-blockers at baseline. A lower dose should be considered for patients with a history of hepatic impairment. Your doctor will check how well your kidneys are working with regular blood tests. Losartan Potassium should be swallowed with a glass of water. potassium-sparing diuretics: amiloride, triamterene, spironolactone) or may increase potassium levels (e.g. Plasma clearance of losartan and its active metabolite is about 600 mL/min and 50 mL/min, respectively. The pharmacokinetics of losartan have been investigated in 50 hypertensive paediatric patients > 1 month to < 16 years of age following once daily oral administration of approximately 0.54 to 0.77 mg/ kg of losartan (mean doses). If you're going to be put to sleep for an operation using a general anaesthetic, tell your doctor that you're taking losartan. After oral intake the administration of a sufficient dose of activated charcoal is indicated. Talk to your doctor, as other medicines might be better while you are breastfeeding. To email a medicine you must sign up and log in. Initially 50 mg once daily for several weeks, then increased if necessary to 100 mg once daily. It does this by reducing the amount of protein you lose through your kidneys and by reducing high blood pressure. During administration of losartan, removal of the angiotensin II negative feedback on renin secretion leads to increased plasma renin activity (PRA). Given their similar pharmacodynamic properties, these results are also relevant for other ACE-inhibitors and angiotensin II receptor blockers. Pregnancy Categories. When angiotensin II antagonists are administered simultaneously with NSAIDs (i.e. Small amounts of losartan may get into breast milk. Based on pharmacokinetic data which demonstrate significantly increased plasma concentrations of losartan in cirrhotic patients, a lower dose should be considered for patients with a history of hepatic impairment. Although not all of these side effects may occur, if they do occur they may need medical attention. When losartan is administered orally, about 4% of the dose is excreted unchanged in the urine, and about 6% of the dose is excreted in the urine as active metabolite. Packs of 10, 14, 20, 21, 28, 28 (cal), 30, 50x1, 56, 60, 98, 98 (cal), 100, 210, 250, 280 tablets, HDPE bottle pack(s): HDPE bottles with silica gel desiccant contained in the polypropylene lid containing 100 and 250 film-coated tablets, 12 . Your doctor will probably advise you to stop taking losartan 24 hours before surgery. The usual starting and maintenance dose is 50 mg once daily for most patients. For patients who can swallow tablets, the recommended dose is 25 mg once daily in patients >20 to <50 kg. At the end of three weeks, losartan administration once daily lowered trough blood pressure in a dose-dependent manner. The primary endpoint of this prospective study was the all-cause mortality. There's very little information about taking herbal remedies and supplements with losartan. Eating a healthy, balanced diet can help if you have high blood pressure. Losartan is not normally recommended in pregnancy or when breastfeeding. Investigators were instructed to titrate the study medication to 100 mg daily as appropriate; 72 % of patients were taking the 100 mg daily dose for the majority of the time. Treatment with losartan resulted in a 13.0% risk reduction (p=0.021, 95 % confidence interval 0.77-0.98) compared with atenolol for patients reaching the primary composite endpoint. The rates of cardiovascular death and myocardial infarction were not significantly different between the treatment groups. The combination of losartan with a beta-blocker should be used with caution (see section 5.1). No, there's no evidence that losartan is addictive. 722 patients over 65 years old with New York Heart Association class II-IV heart failure and ejection fractions less than 40% were randomised to losartan or captopril. a cardiovascular event (e.g. The mean length of follow up was 4.8 years. Although consideration should be given to initiating therapy with 25 mg in patients over 75 years of age, dosage adjustment is not usually necessary for the elderly. Dose adjustment is not usually necessary for the elderly. The plasma concentrations of the active metabolite are not altered in patients with renal impairment or in haemodialysis patients. This site uses cookies. The hypertensive patients (ages 6 through 18 years) were randomised to receive either losartan (n=30) or amlodipine (n=30). Blood pressure was significantly lowered to similar levels in the two groups. Mean peak concentrations of losartan and its active metabolite are reached in 1 hour and in 3-4 hours, respectively. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

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